Medicinal Plant Biotechnology, 2 Volume Set From Basic Research to Industrial Applications

by Kayser, Oliver; Quax, Wim J.

Edition: 1st

ISBN13: 9783527314430

ISBN10: 3527314431

Format: Hardcover

Pub. Date: 2006-12-15

Publisher(s): Wiley-Blackwell

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Summary

This unique overview of plants and transgenic techniques of great scientific, medicinal and economic value for both industry and academia covers the whole spectrum from cell culture techniques, via genetic engineering and secondary product metabolism right up to the use of transgenic plants for the production of bioactive compounds. Practical examples are given throughout, including the production of cancer therapeutics, functional food, and flavor compounds in plants.Of particular interest to the pharmaceutical and biotechnological industries, as well as medicinal chemists, biochemists, and molecular biologists.

Author Biography

Prof. Oliver Kayser studied pharmacy at the University M++nster. He received his PhD and his postdoctoral qualification (Habilitation) from the Free University Berlin in 1997 and 2003. In 2004 he was appointed Assistant Professor at the University Groningen for Pharmaceutical Biology. His research interests are phytochemstry, combinatorial biosynthesis and plant biotechnology. He has published more than 100 peer reviewed papers and proceedings and has authored and edited 5 books.

Professor Wim Quax is head of the laboratory of pharmaceutical biology in the Groningen Research Institute of Pharmacy in the Netherlands. He has published more than 70 peer reviewed papers, and is member of numerous scientific organisations and committees.

Preface
Foreword
List of Contributors
Color Plates

Linking Plants, Genes, and Biotechnology
The Engineering of Medicinal Plants: Prospects and Limitations of Medicinal Plant Biotechnology
Introduction
Genetic Transformation and Production of Transgenic Plants
Pathway Engineering and Combinatorial Biosynthesis
Bioprocessing
Plant Propagation
Bioanalytics and Metabolomics
Future Prospects.References.
Metabolomics
Introduction
Analytical Methods
Data Handling
The General Set-Up of a Metabolomics Project
Applications
Conclusions
References
HPLC-NMR Techniques for Plant Extract Analysis
Introduction
Hyphenation of Separation Techniques and Spectroscopic Methods
Direct HPLC-NMR Methods
Indirect HPLC-NMR Methods.
HPLC-SPE-NMR
Cryogenically Cooled NMR Probes
Miniaturization
Conclusions
References
Plant-Associated Microorganisms (Endophytes) as a New Source of Bioactive Natural Products
Abstract
Introduction
Why Are There Needs for New Medicines?
Natural Products in Medicine
Endophytic Microbes
Rationale for Plant Selection
Endophytes and Biodiversity
Endophytes and Natural Products
Surprising Results from Molecular Biology Studies on Pestalotiopsis microspora
Concluding Statements
Acknowledgments
References
DNA Profiling of Plants
Introduction
Methodology of Plant DNA Profiling
Applications
Conclusions
References
Bioprospecting: The Search for Bioactive Lead Structures from Nature
Abstract
Introduction
The Function of Secondary Metabolites
Modes of Action
The Utilization of Secondary Metabolites in Medicine
Conclusions
Key references
Biotechnological Approaches for the Production of some Promising Plant-Based Chemotherapeutics
Abstract
Introduction
Production by Plant Cell Cultures
Biotechnological Approaches for Production
Future Prospects
References
Genetic Modifications, Transgenic Plants and Potential of Medicinal Plants in Genetechnology and Biotechnology
In-Vitro Culturing Techniques of Medicinal Plants
Introduction
Basic Methods and Techniques
Protoplast Technology
Special Techniqu
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