Foreword |
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xi | |
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Preface |
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xiii | |
Acknowledgments |
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xv | |
Introduction |
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1 | (2) |
Chapter 1. What Is a Drug? |
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3 | (6) |
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Golden Age of Pharmacology |
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4 | (1) |
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Why Study the Brain-Behavior Relationship? |
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4 | (2) |
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6 | (3) |
Chapter 2. Is There a Brain-Behavior Relationship? |
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9 | (8) |
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9 | (1) |
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10 | (1) |
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10 | (1) |
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Electricity, the Brain, and Behavior |
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11 | (1) |
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Neurons and Synapses Discovered |
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11 | (1) |
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Evidence of a Brain-Behavior Relationship |
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12 | (1) |
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12 | (2) |
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Does the Brain Store Memories? |
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14 | (1) |
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Why Do People Take Drugs? |
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14 | (3) |
Chapter 3. Pharmacokinetics: How Do Drugs Get There? |
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17 | (16) |
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Entering the Circulation: The First Step |
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17 | (8) |
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Getting the Drug Out of the Blood: The Second Step |
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25 | (3) |
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Describing the Relationship Between Dose and Effect |
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28 | (2) |
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30 | (3) |
Chapter 4. Neuroanatomy: Where Do Psychoactive Drugs Act? |
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33 | (12) |
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The Brain Is the Target of Psychoactive Drugs |
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33 | (2) |
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Cerebral Cortex (Cerebrum) |
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35 | (2) |
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37 | (1) |
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38 | (5) |
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43 | (2) |
Chapter 5. Neurophysiology: How Do Psychoactive Drugs Act? |
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45 | (10) |
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45 | (1) |
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Neurons, Glia, and Neurotransmission |
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45 | (2) |
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47 | (1) |
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Resting and Action Potentials Explained |
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47 | (2) |
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Non—Ion-Gated Neurotransmission |
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49 | (1) |
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What Are Neurotransmitters? |
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49 | (1) |
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Where Do Neurotransmitters Come From? |
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50 | (2) |
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Where Do Neurotransmitters Go? |
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52 | (1) |
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52 | (1) |
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Neurotransmission, Drugs, and Behavior |
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53 | (2) |
Chapter 6. Alcohol: The Socially Accepted Addictive Beverage |
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55 | (20) |
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55 | (1) |
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56 | (2) |
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How Does Alcohol Get into the Blood? |
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58 | (1) |
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Factors Affecting Absorption |
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59 | (5) |
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Neuropharmacology of Intoxication |
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64 | (1) |
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Oxidation and Elimination |
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65 | (2) |
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67 | (1) |
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68 | (1) |
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Biobehavioral Effects of Alcohol Intoxication |
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68 | (1) |
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Driving and Other Complex Tasks in Which Attention Is Divided |
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69 | (2) |
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71 | (2) |
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Other Medical Consequences of Alcohol |
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73 | (2) |
Chapter 7. Cocaine and Other Stimulants: Drugs That Make Us High |
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75 | (12) |
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77 | (3) |
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Harmful Side Effects of Cocaine |
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80 | (1) |
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Abuse of and Dependence on Cocaine |
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81 | (1) |
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82 | (1) |
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Does Cocaine Affect Driving? |
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83 | (1) |
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83 | (1) |
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Medical Uses of Amphetamines |
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84 | (1) |
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Abuse of and Dependence on Amphetamines |
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85 | (1) |
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85 | (2) |
Chapter 8. Opioids: Drugs That Calm Our Pain |
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87 | (12) |
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87 | (2) |
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89 | (1) |
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89 | (1) |
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90 | (1) |
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90 | (2) |
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92 | (1) |
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92 | (2) |
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94 | (1) |
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Distribution and Elimination |
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94 | (1) |
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95 | (1) |
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Harmful Effects: Myths and Realities |
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95 | (1) |
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Abuse of and Dependence on Opioids |
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96 | (3) |
Chapter 9. Marijuana: The Illegal Recreational Plant |
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99 | (20) |
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99 | (2) |
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101 | (1) |
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How Is Marijuana Administered? |
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101 | (2) |
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103 | (1) |
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Different Types of Marijuana |
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103 | (1) |
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104 | (1) |
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Neuropharmacology of Cannabinoids |
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105 | (1) |
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Half-Life and Measurement of THC |
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106 | (1) |
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Biobehavioral Effects and Use of Marijuana |
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107 | (3) |
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Harmful Effects: Myths and Realities |
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110 | (6) |
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116 | (1) |
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117 | (1) |
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Legal Penalties for Marijuana Possession |
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118 | (1) |
Chapter 10. Anxiolytics: Drugs That Calm Us Down |
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119 | (14) |
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119 | (2) |
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What Are Anxiety Disorders? |
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121 | (1) |
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Where Does Anxiety Begin? |
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122 | (1) |
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Pharmacological Treatment of Anxiety |
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122 | (1) |
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Absorption, Distribution, and Elimination |
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123 | (1) |
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How Do Benzodiazepines Work? |
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124 | (3) |
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Where Are Benzodiazepine Receptors? |
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127 | (1) |
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Biobehavioral Effects of Benzodiazepines |
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127 | (2) |
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Benzodiazepines and the Fetus |
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129 | (1) |
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Abuse of and Dependence on Benzodiazepines |
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129 | (1) |
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Other Anxiolytic Medications |
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130 | (1) |
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Guidelines for the Use of Anxiolytic Drugs |
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130 | (3) |
Chapter 11. Antidepressants: Drugs That Lift Us Up |
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133 | (10) |
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133 | (2) |
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135 | (1) |
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Monoamine Oxidase Inhibitors |
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136 | (2) |
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138 | (1) |
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138 | (1) |
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Tricyclic Antidepressants |
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138 | (1) |
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Selective Serotonin Reuptake Inhibitors |
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139 | (1) |
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139 | (4) |
Chapter 12. Antipsychotics: Drugs That Make Us Sane |
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143 | (16) |
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143 | (1) |
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Symptoms of Schizophrenia |
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144 | (1) |
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Early Treatments for Schizophrenia |
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145 | (1) |
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Golden Age of Pharmacology |
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146 | (3) |
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Neurotransmitters and Schizophrenia |
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149 | (3) |
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Where in the Brain Do Antipsychotic Medications Work? |
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152 | (1) |
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153 | (1) |
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153 | (2) |
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155 | (4) |
Chapter 13. Addiction Is Not What You Think |
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159 | (8) |
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159 | (3) |
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Neurochemical Dysfunction as a Cause of Addictions |
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162 | (3) |
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165 | (2) |
Notes |
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167 | (4) |
Selected Bibliography |
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171 | (8) |
Index |
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179 | |