Combinatorial Chemistry and Molecular Diversity in Drug Discovery

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Edition: 1st
Format: Hardcover
Pub. Date: 1998-08-27
Publisher(s): Wiley-Liss
List Price: $244.21

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Summary

Combinatorial Chemistry and Molecular Diversity in Drug Discovery is one of the first comprehensive books to cover this explosive area. It is must reading for medicinal chemists, pharmacologists, molecular biologists, biochemists, enzymologists, and drug discovery research managers in industry, academia, and government.

Author Biography

Eric M. Gordon and James F. Kerwin are the authors of Combinatorial Chemistry and Molecular Diversity in Drug Discovery, published by Wiley.

Table of Contents

Foreword: Combinatorial Chemistry at a Crossroads ix(8)
Walter H. Moos, MitoKor, San Diego, California
Preface xvii(4)
Contributors xxi
PART I. Combinatorial Chemistry and Molecular Diversity: An Introduction 1(178)
1. Historical Overview of the Developing Field of Molecular Diversity
3(14)
John C. Chabala, Pharmacopeia Inc., Princeton, New Jersey
2. Strategies in the Design and Synthesis of Chemical Libraries
17(22)
Eric M. Gordon, Versicor, Inc., Fremont, California
3. Solid-Phase Peptide Synthesis, Lead Generation, and Optimization
39(72)
Bruce Seligman, SIDDCO, Tucson, Arizona
Michael Lebl, Trega Biosciences, San Diego, California
Kit S. Lam, Arizona Cancer Center, Tucson, Arizona
4. Light-Directed Chemical Synthesis of Positionally Encoded Peptide Arrays
111(22)
Jeffrey W. Jacobs
Dinesh V. Patel
Zhengyu Yuan, Versicor, Inc., Fremont, California
Christopher P. Holmes
John Schullek, Affymax Research Institute, Palo Alto, California
Valery V. Antonenko
J. Russell Grove
Vicolay Kulikov
Derek Maclean
Marc Navre
Cindy Nguyen
Lihong Shi
Arathi Sundaram
Steven A. Sundberg, Affymax Research Institute, Santa Clara, California
5. Conformationally Restricted Peptide and Peptidomimetic Libraries
133(18)
Alex A. Virgilio
Jonathan A. Ellman, Department of Chemistry, University of California at Berkeley, Berkeley, California
6. Submonomer Approaches for the Generation of Molecular Diversity: Nonnatural Oligomer and Organic Template Libraries
151(14)
Lutz S. Richter
Dane A. Goff
Kerry L. Spear
Eric J. Martin
Ronald N. Zuckermann, Chiron Corporation, Emeryville, California
7. Oligonucleotide Libraries as a Source of Molecular Diversity
165(14)
Houng-Yau Mei, Parke - Davis Pharmaceutical Research, Division of Warner - Lambert Company, Ann Arbor, Michigan
Anthony Czarnik, IRORI, La Jolla, California
PART II. Small Molecule Libraries 179(158)
8. Small Molecule Libraries: Overview of Issues and Strategies in Library Design
181(8)
John J. Baldwin, Pharmacopeia, Inc., Princeton, New Jersey
9. Protease Inhibitor Libraries
189(12)
Dinesh V. Patel, Versicor, Inc., Fremont, California
David A. Campbell, Affymax Research Institute, Santa Clara, California
10. Heterocyclic Combinatorial Chemistry: Azine and Diazepine Pharmacophores
201(12)
Mikhail F. Gordeev
Dinesh V. Patel, Versicor, Inc., Fremont, California
11. Scaffolds for Small Molecule Libraries
213(14)
Michael R. Pavia, Millenium Pharmaceuticals Inc., Cambridge, Massachusetts
12. Application of Combinatorial Chemistry to Biopolymers
227(16)
Edmund J. Moran, Ontogen Corp., Carlsbad, California
13. Oligosaccharide and Glycoconjugate Solid-Phase Synthesis Technologies for Drug Discovery
243(28)
Michael J. Sofia, Transcell Technologies, Inc., Cranbury, New Jersey
14. Encoded Combinatorial Chemistry
271(20)
Jeffrey W. Jacobs
Zhi-Jie Ni, Versicor, Inc., Fremont, California
15. Parallel Organic Synthesis in Array Format
291(16)
Steven E. Hall, Sphinx Pharmaceuticals, A Division of Eli Lilly & Co., Durham, North Carolina
16. Synthetic Organic Chemistry on Solid Support
307(30)
Stephen W. Kaldor
Miles G. Siegel, Lilly Research Laboratories, A Division of Eli Lilly & Company, Indianapolis, Indiana
PART III. Automation, Analytical, and Computational Methods 337(50)
17. Automation of Combinatorial Chemistry for Large Libraries
339(10)
Michael Needels
Jeffrey Sugarman, Affymax Research Institute, Palo Alto, California
18. Analytical Chemistry Issues in Combinatorial Organic Synthesis
349(20)
William L. Fitch
Gary C. Look
George Detre, Affymax Research Institute, Santa Clara, California
19. Quantifying Diversity
369(18)
Yvonne C. Martin
Robert D. Brown
Mark G. Bures, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois
PART IV. Biological Diversity 387(32)
20. Protein Scaffolds for Peptide Libraries
389(12)
Ronald H. Hoess, Dupont-Merck Pharmaceutical Company, Wilmington, Delaware
21. Combinatorial Biosynthesis of "Unnatural" Natural Products
401(18)
Chaitan Khosla, Departments of Chemistry and Chemical Engineering, Stanford University, Stanford, California
PART V. Screening 419(26)
22. Strategies for Screening Combinatorial Libraries
421(12)
Bruce A. Beutel, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois
23. Approaches and Technologies for Screening Large Combinatorial Libraries
433(12)
Nolan H. Sigal
Daniel Chelsky, Pharmacopeia, Inc., Princeton, New Jersey
PART VI. Combinatorial Drug Screening and Development 445(54)
24. Combinatorial Drug Discovery: Concepts
447(6)
Judd Berman, Glaxo Wellcome Research Institute, Research Triangle Park, North Carolina
Russell J. Howard, Affymax Research Institute, Santa Clara, California
25. ADME/PK Assays in Screening for Orally Active Drug Candidates
453(22)
Jacqueline A. Gibbons
Eric W. Taylor
Rene A. Braeckman, Chiron Corporation, Emeryville, California
26. Combinatorial Technologies: Prospects and Future Issues
475(8)
James F. Kerwin, Jr., Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois
27. Appendix: Combinatorial Chemistry Information Management
483(16)
David Weininger, Daylight Chemical Information Systems, Inc., Santa Fe, New Mexico
Index 499

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