Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition

by Black; Jonathan

Edition: 4th

ISBN13: 9780849339592

ISBN10: 0849339596

Format: Hardcover

Pub. Date: 2005-12-20

Publisher(s): CRC Press

Other versions by this Author

List Price: ~~$145.00~~

Buy New

Usually Ships in 5-7 Business Days

$144.86

Add to Cart

Rent Textbook

Select for Price

Add to Cart

There was a problem. Please try again later.

Rent Digital

Online:180 Days access
Downloadable:180 Days

$118.80

Online:365 Days access
Downloadable:365 Days

$140.40

Online:1825 Days access
Downloadable:Lifetime Access

$216.00

*To support the delivery of the digital material to you, a non-refundable digital delivery fee of $3.99 will be charged on each digital item.

$118.80*

Add to Cart

Used Textbook

We're Sorry
Sold Out

Buy from our Marketplace starting at $74.01

Summary

Bioengineers need a thorough grounding in biocompatibility - the biological performance of materials. Until now, there were no publications suitable for a neophyte in the field; prior publications were either not comprehensive or focused on rather narrow interests. Drawing on the author's 35 years of experience as a teacher, researcher, and consultant in biomaterials science and engineering (BSE), Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition focuses primarily on principles of biological performance at a relatively fundamental level, analyzing interactions between living organisms and nonliving materials used in medical devices - the subject that sets BSE apart as a distinct field of investigation.Following an introductory section, the book is divided into three sections: the material response to biological systems, host response to biomaterials, and test methods for determining biological response in vitro as well as in animal models and clinical settings.Supplemental "Interparts" summarize the physical properties of commonly used metallic, polymeric, and ceramic biomaterials. They also provide a guide to understanding the clinical performance of implanted biomaterials.

Part I General Considerations

Biocompatibility: Definitions and Issues

(14)

Introduction

(2)

Biological Performance

(1)

Consensus Definitions

(1)

Discussion

(3)

The Discipline of Biomaterials

(2)

Afterword: Paradigmatic Shift

(5)

References

(1)

Bibliography

(2)

Introduction to the Biological Environment

(18)

General Considerations

(1)

Comparison of External and Internal Conditions

(1)

Problems in Definition of the Biological Environment

(2)

Elements of the Biological Environment

(2)

Implant Life History

(6)

Preimplantation Handling Effects

(7)

References

(1)

Bibliography

(5)

Part II Material Response: Function and Degradation of Materials In Vivo

Swelling and Leaching

(14)

Introduction

(1)

Fick's Laws of Diffusion

(1)

Absorption

(2)

Examples of Undesirable Absorption

(4)

Osmotic Equilibrium

(1)

Leaching

(1)

Example of Planned Leaching: Drug Release

(2)

Effects of Swelling and Leaching

(3)

References

(1)

Bibliography

(2)

Corrosion and Dissolution

(24)

Chemistry of Corrosion

(1)

Classification of Reactions

(1)

The Pourbaix Diagram

(3)

The Electrochemical Series

(2)

Corrosion Rate

(1)

Potential-Current Relationships in Corrosion

(1)

Forms of Corrosion

(6)

Corrosion in Implant Applications

(2)

Engineering Variables Affecting Corrosion Rates

(1)

Corrosion Factors Peculiar to Biological Environments

(1)

Ceramic Dissolution

(1)

Polymer Dissolution

(1)

Final Remarks

(3)

References

(1)

Bibliography

(2)

Reactions of Biological Molecules with Biomaterial Surfaces

(14)

Introduction

(1)

Denaturation

(1)

Organometallic Compounds

(3)

Mechanical Aspects of Interfaces

(3)

Results of Interfacial Adhesion of Molecules

(2)

Effects of Charged Interfaces and Ions

(1)

Final Comments

(4)

References

(1)

Bibliography

(3)

Mechanics of Materials: Deformation and Failure

(20)

Introduction

(1)

Mechanics of Materials

(3)

Elastic Modulus

(6)

Yield Strength

(1)

Fracture Strength

(7)

Final Comment

104

(3)

References

104

(1)

Bibliography

105

(2)

Friction and Wear

107

(18)

Introduction

107

(1)

Friction

107

(2)

Lubrication

109

(5)

Wear

114

(8)

Conclusions

122

(3)

References

122

(1)

Bibliography

123

(2)

Interpart 1 Implant Materials: Properties

125

(202)

Introduction

125

(1)

Metals

126

(3)

Polymers

129

(2)

Ceramics

131

(1)

Composites

132

(7)

References

134

(1)

Bibliography

135

(4)

Part III Host Response: Biological Effects of Implants

The Inflammatory Process

139

(26)

Introduction

139

(1)

The Inflammatory Response

139

(11)

Infection

150

(5)

Effects of Implant Degradation Products

155

(5)

A Final Comment

160

(5)

References

160

(2)

Bibliography

162

(3)

Coagulation and Hemolysis

165

(18)

Introduction

165

(1)

The Coagulation Cascade

165

(5)

Approaches to Thromboresistant Materials Development

170

(6)

Hemolysis

176

(3)

Final Comments

179

(4)

References

180

(1)

Bibliography

181

(2)

Adaptation

183

(20)

Introduction

183

(1)

Tissue Growth Strategies

183

(3)

Examples of Adaptation in Implant Applications

186

(11)

A Final Comment on Adaptation

197

(6)

References

199

(2)

Bibliography

201

(2)

In Vitro Tissue Growth and Replantation

203

(22)

General Considerations

203

(1)

What Is Tissue Engineering?

204

(2)

The Cell-Receptor Paradigm

206

(4)

Matrices and Cell Sources

210

(4)

Thinking Twice about Tissue Engineering

214

(6)

Some Final Comments

220

(5)

References

222

(1)

Bibliography

223

(2)

Allergic Foreign Body Response

225

(20)

Specific vs. Nonspecific Response

225

(1)

Mechanisms of Immune Response

226

(4)

Classes of Hypersensitivity Reactions

230

(1)

Hypersensitivity Reactions Associated with Implants

230

(10)

Final Comment

240

(5)

References

241

(2)

Bibliography

243

(2)

Chemical and Foreign-Body Carcinogenesis

245

(28)

Definitions

245

(1)

Chemical Carcinogenesis

246

(11)

Foreign Body Carcinogenesis

257

(5)

Nonspecific Carcinogenesis

262

(1)

Evidence for Implant Carcinogenesis in Humans

263

(10)

References

268

(2)

Bibliography

270

(3)

Mineral Metabolism

273

(18)

Introduction

273

(1)

Iron Metabolism

274

(9)

Chromium Metabolism

283

(2)

Human Dietary Metal Intake

285

(6)

References

288

(1)

Bibliography

289

(2)

Systemic Distribution and Excretion

291

(26)

Introduction

291

(1)

Movement of Solid Bodies

291

(5)

Transport of Dissolved Species

296

(5)

Distribution and Excretion of Dissolved Species

301

(10)

Final Comment

311

(6)

References

312

(3)

Bibliography

315

(2)

Effects of Degradation Products on Remote Organ Function

317

(10)

Introduction

317

(1)

Examples of Systemic Effects

318

(3)

A Review of Systemic Aspects of Host Response

321

(2)

A Final Comment

323

(4)

References

325

(1)

Bibliography

326

(1)

Interpart 2 Implant Materials: Clinical Performance

327

(132)

Introduction

327

(3)

An Example: Total Hip Replacement

330

(2)

A Final Word

332

(5)

References

332

(1)

Bibliography

333

(4)

Part IV Methods of Testing for Biological Performance

In Vitro Test Methods

337

(18)

Test Strategies

337

(1)

In Vitro Test Types

338

(1)

Tissue Culture Tests

338

(9)

Blood Contact Tests

347

(3)

Final Comments

350

(5)

References

351

(2)

Bibliography

353

(2)

In Vivo Implant Models

355

(28)

Introduction

355

(3)

Test Types

358

(12)

A Final Comment

370

(13)

References

370

(3)

Bibliography

373

(1)

Appendices

374

(9)

Clinical Testing of Implant Materials

383

(20)

Goal of Clinical Trials

383

(1)

Design of Clinical Trials

384

(8)

Conclusions from Clinical Trials

392

(2)

Aspects of the Decision for General Clinical Use

394

(4)

Final Comments

398

(5)

References

400

(1)

Bibliography

401

(2)

Standardization and Regulation of Implant Materials

403

(24)

Historical Perspective

403

(1)

Drug Standardization Activities

404

(2)

Biomaterials Standardization Activities

406

(9)

U.S. Federal Regulation of Medical Devices and Biomaterials

415

(4)

Regulation of Materials for Implants

419

(3)

The Biomaterials Supply ``Crisis''

422

(5)

References

423

(1)

Bibliography

424

(3)

Design and Selection of Implant Materials

427

(14)

Introduction

427

(2)

The Design Process

429

(9)

The Value of Prospective Design

438

(3)

References

439

(1)

Bibliography

440

(1)

Clinical Performance of Biomaterials

441

(18)

Historical Aspects

441

(2)

Procedures for Device Retrieval and Analysis

443

(4)

Common Concerns about Device Retrieval and Analysis

447

(3)

Proposed National Implant Data Retrieval and Analysis Program (NIDRA)

450

(1)

Elements of a NIDRA System

451

(4)

Autopsy Retrieval Studies

455

(1)

Concluding Remarks

456

(3)

References

457

(1)

Bibliography

457

(2)

Glossary

459

(12)

Introduction

459

(1)

Glossary

460

(9)

Deprecated Terms

469

(2)

References

470

(1)

Index

471

Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition

Buy New

Rent Textbook

Rent Digital

Used Textbook

How Marketplace Works:

Summary

Table of Contents

Digital License